PROBE
Individual Probe
Classes of Disease or Gene
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01
1.Breast cancer, lung cancer, renal cell carcinoma
Breast Cancer
Gene: HER2、CEP17、HER3、CEP12、HER4、CEP2、TOPO2A、NF1、BRCA1、P53。Lung Cancer
Gene: ALK(Fusion assay)、EML4(Fusion assay)、ALK(Break-apart assay)(Fusion assay)、EML4(Break-apart assay)(Fusion assay)、ROS1(Break-apart assay)、RET 5’、RET 3’。Renal Cell Carcinoma / Alveolar Soft Part Sarcoma
Gene: 3’-TFE3 Centromeric、3’-TFE3 Centromeric、5’-TFE3 Telomeric、5’-TFE3 Telomeric。
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02
2.Prostate cancer, colorectal cancer, lung cancer, etc.
EWSR1 rearrangement
Gene: EWSR1-5'、EWSR1-3'、EWSR1-3'。Desmoplastic small round cell tumor
Gene: EWSR1、WT1(green)、WT1(green)。Prostate Cancer
Gene: TMPRSS2 5'、ERG 5’、ERG 3’、PTEN、CEP10。Colorectal Cancer / Lung Cancer
Gene: EGFR(red)、CEP 7、CEP 7、c-MET(red)。
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03
3.Hepatoma, Lymphoma, Dermatofibrosarcoma protuberans, etc.
Hepatoma
Gene: CLIC1、CEP 60。Lymphoma
Gene:FGFR1、PDGFRA、PDGFRB。Dermatofibrosarcoma protuberans
Gene: COL1A1、platelet-derived growth factor B chain (PDGFB)。Fip1-like 1 (FIP1L1) gene
Gene: FIP1L1。Pre-natal
Gene: RB1(red)、ERG 5’(green)。
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04
4.LNX1, CHIC2, Congenital fibrosarcoma, Synovial Sarcoma, etc.
Homo sapiens ligand of numb-protein X 1 (LNX1)
Gene: LNX1。Homo sapiens cysteine-rich hydrophobic domain 2 (CHIC2)
Gene: CHIC2。(Congenital fibrosarcoma / mesoblastic nephroma) ETV6-NTRK3
Gene: ETV6(red) Telomeric to ETV6、ETV6(green) Centromeric to ETV6、NTRK3(red) Telomeric to NTRK3、NTRK3(green) Centromeric to NTRK3。Synovial Sarcoma
Gene: SS18 3’、 SS18 3’、 SS18 3’、 SS18 5’、 SS18 5’、 SS18 5’。
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05
5.FUS rearrangement, MYEOV-IGH t(11;14), MPO, BCR/ABL
FUS rearrangement (Break-apart)
Gene: FUS-5’(red)、FUS-5’(red)、FUS-3’(green)、FUS-3’(green)。MYEOV-IGH t(11;14) dual color, dual-fusion assay
Gene: Homo sapiens myeloma overexpressed (MYEOV) 5’、(MYEOV) 3’、IGH 5’、IGH 3’。Myeloperoxidase(MPO)
Gene: MPO。BCR/ABL dual color, dual-fusion probe
Gene: BCRBCR(Breakpoint cluster region)。
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06
6.Tuberous sclerosis, gastric cancer, hTERC(3q26)/3q11, etc.
Tuberous Sclerosis
Gene: TSC-1、TSC-2、CEP16、CEP16、CEP16、CEP16(q12.1)。NPC/ EBV-related gastric cancer
Gene: UBR5-5’、ZNF423-5’、ZNF423-3’、CEP18(aqua)。hTERC(3q26) / 3q11
Gene: hTERC、3q11。AML(RUNX1)/ETO(RUNX1T) t(8;21) Dual-color Fusion
Gene: AML(RUNX1)、ETO(RUNX1T)。
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07
7.PML/RARA t(15,17) Fusion and others
PML/RARA t(15,17) Fusion
Gene: PML、RARA。TEL/AML t(12,21) Fusion
Gene: TEL、AML。MYC/IGH t(8;14) Fusion
Gene: MYC、IGH。BCL1/IGH t(11;14) Fusion
Gene: BCL1。BCL2/IGH t(14;18) Fusion
Gene: BCL2。MALT (18q21) Break
Gene: MALT。BCL6 (3q27)
Gene: BCL6-5'、BCL6-3'。p16(9q21)/ 9q21
Gene: p16。MYCN (2p24) /LAF (2q21)
Gene: MYCN、LAF。1p/19q deletion
